Fonts like Dyslexie and OpenDeyslexic claim to have been designed with dyslexics in mind, mostly by weighting the bottom of glyphs heavier than the top. It’s thought that by constantly drawing the eye toward the baseline, dyslexic readers won’t wander or get distracted.
However, there is no evidence that these fonts improve readability for dyslexics. In fact, one study conducted by researchers at the Universitat Pompeu Fabra showed no improvement in readability at all for dyslexics using these fonts. Instead sans-serif fonts like Arial, Courier, Verdana, and Helvetica were most effective, although there is some question as to whether this was just due to familiarity.
There is more to typography than fonts, though. My suspicion is that better typography for dyslexia is also better typography for everybody. We see a general trend in web typography toward designs that focus the reader’s attention on the text. Consider sites such as Medium, which remove visual noise (sidebars, navigation) and use larger type sizes, contrasting type styles, and more white space—especially line height—all of which help dyslexics and the general reading population alike.
Read more: QuickPanel: Dyslexia | UX Magazine.